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Possible side effects include:
- Nausea and vomiting
- Diarrhea
- Rash
- Mild hair loss
- Headache
- Mouth sores
- Reduced immune function and increased risk of infection
More serious problems may include:
- Blood problems
- Kidney problems
- Stomach or liver problems
- Cancer Lung Inflammation
Note: Methotrexate should not be taken:
- By women who are pregnant or nursing
- By men who want to get their partner pregnant (methotrexate gets into sperm)
- With alcohol
- With non-steroidal anti-inflammatory (NSAID) pain medications