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Safety Issues
Studies in humans and animals suggest that vanadium can cause toxic effects and might accumulate in the body if taken to excess. 1 2 3 4 The safe upper intake level for adults has been set at 1.8 mg. 5 Maximum safe doses for children have not yet been determined.
Another potential risk with vanadium involves its purported benefits. If vanadium does, in fact, improve blood sugar control in people with diabetes, the net result could be a potentially dangerous fall in blood sugar levels (hypoglycemia). For this reason, medical supervision is recommended before adding vanadium to a regimen of standard diabetes medications.
Interactions You Should Know About
- If you are taking insulin or oral diabetes medications : Seek medical supervision before taking vanadium because you may need to reduce your dose of diabetes medication.
References
- Domingo JL, Gomez M, Llobet JM, Corbella J, Keen CL. Oral vanadium administration to streptozotocin-diabetic rats has marked negative side-effects which are independent of the form of vanadium used. Toxicology. 66(3):279-87.
- Srivastava AK. Anti-diabetic and toxic effects of vanadium compounds. Mol Cell Biochem. 206(1-2):177-82.
- Sanchez DJ, Colomina MT, Domingo JL. Effects of vanadium on activity and learning in rats. Physiol Behav. 63(3):345-50.
- Domingo JL. Vanadium: a review of the reproductive and developmental toxicity. Reprod Toxicol. 1996;10:175-182.
- Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc (2001). National Academies Press website. Available at: http://www.nap.edu. Accessed October 4, 2001.
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