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Tried or prescribed Tripterygium wilfordii? Share your experience.
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Safety Issues
Trypterygium is a toxic herb: various components of trypterygium can cause liver injury, genetic damage, and birth defects. 1 2 3 4 It is thought, but not proven, that certain chemical extracts of trypterygium are safe if used within proper dosage limits. 5 All forms of the herb should be avoided by pregnant or nursing women, young children, and those with kidney or liver disease.
References
- Peng B, Miao MS, Wang YL, et al. Initial discussion of mice acute hepatic injury caused by tripterygium glycosides [in Chinese]. Zhongguo Zhong Yao Za Zhi. 2004;28:1067–70.
- Takei A, Nagashima G, Suzuki R, et al. Meningoencephalocele associated with Tripterygium wilfordii treatment. Pediatr Neurosurg. 1997;27:45–48.
- Chan WY, Ng TB. Adverse effect of Tripterygium wilfordii extract on mouse embryonic development. Contraception. 1995;51:65–71.
- Xu W, Ziqing L, Yinrun D, et al. Tripterygium hypoglaucum (level) Hutch induces aneuploidy of chromosome 8 in mouse bone marrow cells and sperm. Mutagenesis. 2004;19:379–82.
- Tao X, Lipsky PE. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum Dis Clin North Am. 2000;26:29–50, viii.
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