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Therapeutic Uses
Various websites promote SOD for a wide variety of health problems, from preventing aging to enhancing sports performance. However, as noted above, oral SOD supplements may be ineffective due to poor absorption.
A bit of evidence hints that SOD injections may reduce scarring caused by radiation therapy 1 2 3 and also decrease symptoms of osteoarthritis . 4 SOD applied directly to wounds may enhance wound healing, according to experiments in animals. 5 In test-tube and animal studies , genetic manipulation has been used to increase SOD levels, in hopes of finding anti-aging effects, but the results have been mixed. 6 7 8 Inhaled SOD appears to be useful for premature infants, helping to prevent a condition called respiratory distress syndrome. 9 10 However, the only evidence for benefits with any oral form of SOD is a study in animals involving the special liposome form of the supplement mentioned above. It found possible anti-inflammatory effects. 11
References
- Delanian S, Martin M, Bravard A, Luccioni C, Lefaix JL. Cu/Zn superoxide dismutase modulates phenotypic changes in cultured fibroblasts from human skin with chronic radiotherapy damage. Radiother Oncol. 58(3):325-31.
- Delanian S, Baillet F, Huart J, Lefaix JL, Maulard C, Housset M. Successful treatment of radiation-induced fibrosis using liposomal Cu/Zn superoxide dismutase: clinical trial. Radiother Oncol. 32(1):12-20.
- Housset M, Baillet F, Michelson AM, Puget K. [Action of liposomal superoxide dismutase on measurable radiation-induced fibrosis] Ann Med Interne (Paris). 140(5):365-7.
- Ratcheva I, Stefanova Z, Vesselinova A, Nikolova S, Kujumdjieva A, Neychev H. Treatment of adjuvant arthritis in mice with yeast superoxide dismutase. Pharmazie. 55(7):533-7.
- Vorauer-Uhl K, Fürnschlief E, Wagner A, Ferko B, Katinger H. Reepithelialization of experimental scalds effected by topically applied superoxide dismutase: controlled animal studies. Wound Repair Regen. 10(6):366-71.
- Flanagan SW, Anderson RD, Ross MA, Oberley LW. Overexpression of manganese superoxide dismutase attenuates neuronal death in human cells expressing mutant (G37R) Cu/Zn-superoxide dismutase. J Neurochem. 81(1):170-7.
- Gallagher IM, Jenner P, Glover V, Clow A. CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months. Neurosci Lett. 289(3):221-3.
- Huang TT, Carlson EJ, Gillespie AM, Shi Y, Epstein CJ. Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci. 2000;55:B5–9.
- Davis JM, Rosenfeld WN, Richter SE, et al. The effects of multiple doses of recombinant human CuZn superoxide dismutase (rhSOD) in premature infants with respiratory distress syndrome (RDS). Pediatr Res. 1999;45:193A (Abstract no.1129).
- Davis JM, Richter SE, Biswas S, Rosenfeld WN, Parton L, Gewolb IH, Parad R, Carlo W, Couser RJ, Baumgart S, Atluru V, Salerno L, Kassem N. Long-term follow-up of premature infants treated with prophylactic, intratracheal recombinant human CuZn superoxide dismutase. J Perinatol. 20(4):213-6.
- Regnault C, Roch-Arveiller M, Tissot M, Sarfati G, Giroud JP, Postaire E, Hazebroucq G. Effect of encapsulation on the anti-inflammatory properties of superoxide dismutase after oral administration. Clin Chim Acta. 240(2):117-27.
