Sumatriptan and Naproxen Overview

(soo ma TRIP tan & na PROKS en)

Treximet™

Antimigraine Agent; Nonsteroidal Anti-inflammatory Drug (NSAID), Oral; Serotonin 5-HT1B, 1D Receptor Agonist

• This medicine may increase the risk of heart attack, stroke, and high blood pressure. This has been observed with long-term use or at critical times (right after heart surgery). Use caution if you have risk factors for heart disease (high blood pressure, high cholesterol, overweight, diabetes, cigarette smoking, male older than 40 years of age, other family members with early heart disease, postmenopausal female).

• This medicine may increase the risk of ulcer or bleeding from the stomach or intestines. Talk with healthcare provider.

• There is a risk of serotonin syndrome when using this medicine with certain medicines for depression or weight loss. The syndrome is caused by too much serotonin in the body. Signs include agitation, changes in blood pressure, diarrhea, fast heartbeat, hallucinations, nausea and vomiting, significant change in balance, and significant change in thinking clearly and logically. Talk with healthcare provider.

• This medicine does not mix well with many medicines. Serious reactions may occur. Check all medicines with healthcare provider.

• Please read the medication guide.

• If you have an allergy to sumatriptan, naproxen, or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Certain types of migraines, chest pain or pressure, diseased arteries going to the legs, heart attack, heart bypass surgery, heart disease, severe liver disease, poor intestinal blood flow, stroke, or uncontrolled high blood pressure.

• If you are using this medicine to prevent migraine headaches.

• If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this medicine is started. Taking the two together could cause dangerously high blood pressure.

• If you have taken almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, or zolmitriptan in the last 24 hours.

• If you have taken ergotamine, methysergide, or dihydroergotamine in the last 24 hours.

• If you are more than 24 weeks pregnant.

• If you are breast-feeding.

• Sumatriptan reduces swelling of blood vessels in the brain that cause the migraine.

• Naproxen blocks production and release of chemicals that cause pain and inflammation.

• Take this medicine with food to prevent stomach upset.

• Swallow whole. Do not chew, break, or crush.

• If your headache returns after the first dose, another dose may be taken 2 hours after the first one.

• This medicine is taken on an as needed basis. Do not take more than 2 tablets in 24 hours.

• Change in condition being treated. Is it better, worse, or about the same?

• Keep a diary of your headaches.

• Dry mouth may cause an increase in cavities. Take good care of your teeth. See a dentist regularly.

• Follow up with healthcare provider.

• Store at room temperature.

• Protect from moisture. Do not store in a bathroom or kitchen.

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

Created: 2008-06-11 09:57:08.0

Modified: 2010-03-22 14:11:40.0

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