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Therapeutic Uses
Strontium has fundamental chemical similarities to calcium. When dietary intake of strontium is raised, strontium begins to take the place of calcium in developing bone. This replacement appears to be beneficial (at least with low doses of strontium—see Safety Issues ), leading to an increase in bone formation, a decrease in bone breakdown, and an overall rise in bone density. 1 2 3 4 The net result is a reduced incidence of fractures due to osteoporosis, according to two very large studies. 5 In addition, highly preliminary evidence hints that strontium might also help prevent cavities by strengthening dental enamel. 6
References
- Reginster JY, Seeman E, DE Vernejoul MC, et al. Strontium ranelate reduces the risk of invertebral fractures in postmenopausal women with osteoporosis: Treatment of Perpheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005 Feb 22 [Epub ahead of print].
- Reginster JY, Meunier PJ. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. Osteoporos Int. 14 Suppl 3():S56-65.
- Reginster JY, Deroisy R, Jupsin I. Strontium ranelate: a new paradigm in the treatment of osteoporosis. DrugsToday (Barc). 2003;39:89–101.
- Reginster JY, Deroisy R, Dougados M, Jupsin I, Colette J, Roux C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. Osteoporos Int. 13(12):925-31.
- Reginster JY, Seeman E, DE Vernejoul MC, et al. Strontium ranelate reduces the risk of invertebral fractures in postmenopausal women with osteoporosis: Treatment of Perpheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab. 2005 Feb 22 [Epub ahead of print].
- Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med. 95(5A):69S-74S.
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