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Safety Issues
Saffron appears to be safe. 1 One study found no serious adverse effects among healthy volunteers given up to 200 mg/day of saffron for one week. 2 It is often said that very high doses of saffron can cause abortion and possible toxic symptoms, but there is no scientific documentation of these supposed effects. However, the so-called meadow saffron, Colchicum autumnale, is highly toxic, and sometimes people mistake one for the other.
Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
References
- Abdullaev Jafarova F, Caballero-Ortega H, Riveron-Negrete L, et al. In vitro evaluation of the chemopreventive potential of saffron [in Spanish]. Rev Invest Clin. 2003;54:430–6.
- Modaghegh MH, Shahabian M, Esmaeili HA, et al. Safety evaluation of saffron ( Crocus sativus ) tablets in healthy volunteers. Phytomedicine. 2008 Aug 5.
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