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Therapeutic Uses
Very preliminary evidence, such as the results of test tube studies , suggests that resveratrol may help prevent heart disease , 1 2 3 and cancer . 4 5 6 7 8 However, not all studies have been favorable. 9 Furthermore, there is some evidence that resveratrol is immediately broken down by the human liver, and thereby does not, in fact, enter the blood stream at any significant level. 10 In any case, only double-blind studies can prove a treatment effective, and none have been reported with resveratrol. (For information on why such studies are essential, see Why Does This Database Rely on Double-Blind Studies? )
References
- Goldberg DM. More on antioxidant activity of resveratrol in red wine [letter]. Clin Chem. 1996;42:113-114.
- Siemann EH, Creasy LL. Concentration of the phytoalexin resveratrol in wine. Am J Enol Vitic. 1992;43:49-52.
- Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the ‘French paradox’? Eur J Endocrinol. 1998;138:619-620.
- Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275(5297):218-20.
- Mgbonyebi OP, Russo J, Russo IH. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int J Oncol. 12(4):865-9.
- Subbaramaiah K, Chung WJ, Michaluart P, Telang N, Tanabe T, Inoue H, Jang M, Pezzuto JM, Dannenberg AJ. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem. 273(34):21875-82.
- Clément MV, Hirpara JL, Chawdhury SH, Pervaiz S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood. 92(3):996-1002.
- Johnson JL, Maddipati KR. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins Other Lipid Mediat. 56(2-3):131-43.
- Turrens JF, Lariccia J, Nair MG. Resveratrol has no effect on lipoprotein profile and does not prevent peroxidation of serum lipids in normal rats. Free Radic Res. 1997;27:557-562.
- Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 32(12):1377-82.
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