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Pyruvate supplies the body with pyruvic acid, a natural compound that plays important roles in the manufacture and use of energy. Pyruvate supplements have become popular with bodybuilders and other athletes, based on claims that pyruvate can reduce body fat and enhance the ability to use energy efficiently. However, at the present time, there is only preliminary evidence that it really works.
Evidence from several small placebo-controlled studies suggests that pyruvate may enhance weight loss . 1
Safety Issues
Both pyruvate and dihydroxyacetone appear to be quite safe, aside from mild side effects, such as occasional stomach upset and diarrhea. Very weak evidence (too weak to get very concerned about) hints that pyruvate supplements might adversely affect cholesterol profile by negating the positive effects of exercise on HDL ("good" cholesterol). 2 Maximum safe dosages for children, women who are pregnant or nursing, or those with liver or kidney disease have not been established.
Keep in mind that if a contaminant were present, even in very small percentages, there could be harmful results due to the enormous doses of pyruvate used. For this reason, you should make sure to use a high-quality product.
