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Safety Issues
In studies, prolotherapy has not caused any serious, irreversible injury. There is usually discomfort after each injection that lasts for a few minutes to several days, but this discomfort is seldom severe. 1 Of more concern, severe headaches have been reported in treatment of low back pain in a minority of patients. Because phenol is a potentially toxic substance, treatment with a dextrose solution alone is preferable.
References
- Klein RG, Eek BC, DeLong WB, Mooney V. A randomized double-blind trial of dextrose-glycerine-phenol injections for chronic, low back pain. J Spinal Disord. 6(1):23-33.