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Safety Issues
Oxerutins appear to be safe and well tolerated. In most studies, oxerutins have produced no more side effects than placebo. For example, in a study of 104 elderly people with venous insufficiency, 26 participants taking oxerutins reported adverse events, compared with 25 in the placebo group. 1 The most commonly observed side effects were gastrointestinal symptoms, headaches, and dizziness. 2 Oxerutins have been given to pregnant women in some studies, with no apparent harmful effects. However, their safety for pregnant or nursing women cannot be regarded as absolutely proven. In addition, the safety of oxerutins has not been established for people with severe liver or kidney disease.
References
- MacLennan WJ, Wilson J, Rattenhuber V, Dikland WJ, Vanderdonckt J, Moriau M. Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: its efficacy and tolerability. Gerontology. 40(1):45-52.
- Wadworth AN, Faulds D. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs. 44(6):1013-32.