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Osteoarthritis and Cyclooxygenase-2 or COX-2 Inhibitors

Written by sshowalter.

Effect of Cyclooxygenase-2 or COX-2 Inhibitors on Osteoarthritis

COX-2 inhibitors work in a way similar to NSAIDs, helping to decrease inflammation, swelling, and joint pain. In addition, they have the benefit of causing less stomach irritation. In particular, COX-2 inhibitors cause far fewer stomach ulcers than do NSAIDs.

Most commonly prescribed COX-2 Inhibitors for Osteoarthritis:

  • Celecoxib (Celebrex)
  • Meloxicam (Mobic)

Read more details about Cyclooxygenase-2 or COX-2 Inhibitors.

Drinking alcoholic beverages or taking NSAIDs while you are using a COX-2 inhibitor can increase your risk of side effects.

Possible side effects include:

  • Liver inflammation
  • Confusion
  • Severe allergic reaction ( hives, difficulty breathing, swelling around the eyes)
  • Stomach upset
  • Heart attack
  • Stroke

References

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Drug Facts and Comparisons . 56th ed. Facts & Comparisons; 2001.

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Hydrocodone and acetaminophen. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 19, 2010. Accessed August 27, 2010.

Lexi-PALS. Duloxetine. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81. Updated March 19, 2010. Accessed November 15, 2010.

Manek NJ, Lane NE. Osteoarthritis: current concepts in diagnosis and management. American Family Physician . 2000;51(6). Available at: http://www.aafp.org/afp/20000315/1795.html.

Mayo Clinic. Osteoarthritis: treatments and drugs. Mayo Clinic website. Available at: http://www.mayocli... . Updated July 8, 2010. Accessed August 27, 2010.

National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: http://www.niams.nih.gov/ .

Propoxyphene. EBSCO Health Library, Lexi-PALS website. Available at: http://www.ebscohost.com/thisTopic.php?marketID=15topicID=81 . Updated March 22, 2010. Accessed August 27, 2010.

3/17/2007 http://www.ebscohost.com/dynamed/what.php : Yelland MJ, Nickles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM. Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology (Oxford). 2007;46:135-140. Epub 2006 Jun.

2/7/2008 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Underwood M, Ashby D, Cross P, et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study. BMJ. 2008;336:138-142. Epub 2007 Dec 4.

10/26/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: Massey T, Derry S, Moore R, McQuay H. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev. 2010;(6):CD007402.

11/15/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php: US Food and Drug

Administration. FDA clears Cymbalta to treat chronic musculoskeletal pain. US Food and Drug Administration website. Available at: http://www.fda.gov.... Published November 4, 2010. Accessed November 12, 2010.

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