Miscellaneous Antidepressants Side Effects and Warnings

Bupropion drugs (generic name for the drugs Wellbutrin, X, Y and Zycam) are widely known to lower the seizure threshold - the balance between excitatory and inhibitory forces in the brain which affects how susceptible one is to seizures. People already susceptible to seizure (especially those with epilepsy) should not take drugs that can lower the seizure threshold as they are already prone to seizures. The prevalence of individuals who had seizures when taking bupropion drugs was so high that the drugs were initially pulled off of the market 1985. They were put back on the market with only a change in the recommended doses (no higher than 450mg).

As with all antidepressants, these miscellaneous antidepressants come with the black box warning stating that "Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality)..."¹ Therefore, suicidal thinking and behavior can increase with the use of these drugs.