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Safety Issues
MSM is a natural component of the foods we normally eat and is not believed to be toxic. A laboratory study examining doses up to 8 g per kilogram of body weight per day (about 250 times the highest dose normally used by humans) reported that no toxic effects were seen. 1 Maximum safe doses for young children, pregnant or nursing women, or people with liver or kidney disease are not known. Possible drug interactions are also not known.
References
- Morton JI, Siegel BV. Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease. Proc Soc Exp Biol Med. 183(2):227-30.