Leuprolide Side Effects and Warnings

What are the precautions when taking this medicine?

• Disease symptoms may worsen before improving.

• If you have mental illness, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Birth control pills and other hormone-based birth control may not work to prevent pregnancy. Use another form of birth control while taking this medicine.

What are some possible side effects of this medicine?

• Flushing. Wearing layers of clothes or summer clothes and cool environment may help.

• Increased bone pain, blood in urine, and difficulty urinating. Usually resolved 1-2 weeks after treatment has started.

• Weakened bones with long-term use.

• Swelling.

• Headache.

• Feeling tired or weak.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Depression.

• Mood changes.

• Inability to sleep.

• Short-term vaginal bleeding.

• Change in sexual ability or desire. This is usually reversible.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Signs or symptoms of depression, suicidal thoughts, nervousness, emotional ups and downs, abnormal thinking, anxiety, or lack of interest in life.

• Significant change in thinking clearly and logically.

• Severe behavioral problems.

• Severe headache.

• Severe nausea or vomiting.

• Swelling or pain of leg or arm.

• Increased bone pain after 2-4 weeks of treatment.

• Severe back pain.

• Feeling extremely tired or weak.

• Unable to pass urine.

• Sudden change in vision.

• Vaginal bleeding for more than 2 months.

• Severe skin irritation.

• Any rash.

• No improvement in condition or feeling worse.