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Safety Issues
When taken in normal dosages, lapacho has not been found to cause any obvious side effects. 1 However, full safety studies have not been performed. Furthermore, the anti-cancer actions of lapachone raise serious concerns about the safety of lapacho for pregnant women, because like cancer cells, cells of a developing fetus rapidly divide. Also, a study in animals found that lapachol caused fetal death. 2 For all these reasons, pregnant or nursing women should not use lapacho. Safety in young children or those with severe liver or kidney disease has also not been established.
References
- Oswald EH. Lapacho. Br J Phytother. 1993/1994;3:112-117.
- Guerra MO, Mazoni AS, Brandão MA, Peters VM. Interceptive effect of Lapachol in rats. Contraception. 60(5):305-7.