Hydrochlorothiazide and Spironolactone Side Effects and Warnings

What are the precautions when taking this medicine?

• Wear disease medical alert identification.

• If you have diabetes, talk with healthcare provider. This medicine can increase blood sugar.

• If you have kidney disease, talk with healthcare provider.

• If you have liver disease, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• If you are taking potassium-containing salt substitutes, potassium-sparing diuretics, or potassium supplements, talk with healthcare provider.

• If you are taking this medicine and have high blood pressure, talk with healthcare provider before using over-the-counter products that may increase blood pressure. These include cough or cold remedies, diet pills, stimulants, ibuprofen or like products, and certain natural products or supplements.

• Avoid alcohol (includes wine, beer, and liquor).

• You can get sunburned more easily. Avoid sun, sunlamps, and tanning beds. Use sunscreen; wear protective clothing and eyewear.

• Watch for gout attacks.

• Tell dentists, surgeons, and other healthcare providers that you use this medicine.

• Tell healthcare provider if you are pregnant or plan on getting pregnant.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Feeling dizzy. Rise slowly over several minutes from sitting or lying position. Be careful climbing.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Dry mouth. Frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• For females, breast tenderness, deepening of voice, or increased hair growth.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Excessive perspiration, dehydration, vomiting, or diarrhea. May lead to low blood pressure.

• Severe dizziness or passing out.

• Severe nausea or vomiting.

• Unable to pass urine.

• For males, enlarged breasts.

• For females, menstrual changes. These include lots of bleeding, spotting, or bleeding between cycles.

• Any rash.

• No improvement in condition or feeling worse.