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Safety Issues
Gentian is somewhat mutagenic, meaning that it can cause changes in the DNA of bacteria. 1 For this reason, gentian should not be taken during pregnancy. Safety in young children, nursing women, or those with severe liver or kidney disease is also not established.
In the short term, gentian rarely causes any side effects, except for occasional worsening of ulcer pain and heartburn. (For some people, it relieves stomach problems.)
References
- Morimoto I, Nozaka T, Watanabe F, et al. Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae). Mutat Res. 1983;116:103–117.