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Usages
Effect of GABA on Generalized Anxiety Disorder
GABA is a naturally occurring neurotransmitter that is used within the brain to reduce the activity of certain nerve systems, including those related to anxiety. For this reason, GABA supplements are...
Read more about Generalized Anxiety Disorder and GABA.
Effect of GABA on Panic Disorder
GABA is a naturally occurring neurotransmitter that is used within the brain to reduce the activity of certain nerve systems, including those related to anxiety typical of panic disorder. For this...
Read more about Panic Disorder and GABA.
Therapeutic Uses
As noted above, GABA is still sometimes recommended for treatment of anxiety and insomnia , but it is almost certainly ineffective for these purposes.
However, evidence from animal studies 1 2 3 4 and preliminary studies in humans 5 hint that GABA supplements can reduce blood pressure .
In the best of the human trials, 39 people with mild hypertension were given either a fermented milk product providing GABA at a dose of 10 mg daily, or placebo, for 12 weeks. 6 The results indicated that GABA modestly decreased blood pressure levels. However, this study was small and suffered from significant problems in design. Additional research will be necessary before GABA can be considered an effective treatment for high blood pressure.
References
- Hayakawa K, Kimura M, Yamori Y. Role of the renal nerves in gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. Eur J Pharmacol. 524(1-3):120-5.
- Hayakawa K, Kimura M, Kasaha K, Matsumoto K, Sansawa H, Yamori Y. Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. Br J Nutr. 92(3):411-7.
- Hayakawa K, Kimura M, Kasaha K, Matsumoto K, Sansawa H, Yamori Y. Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats. Br J Nutr. 92(3):411-7.
- Hayakawa K, Kimura M, Kamata K. Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. Eur J Pharmacol. 438(1-2):107-13.
- Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M, Sansawa H. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr. 57(3):490-5.
- Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M, Sansawa H. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr. 57(3):490-5.
