Estrogens, Conjugated (Equine) Overview

(ES troe jenz KON joo gate ed, EE kwine)

Premarin®

C.E.S.®; Premarin®

C.E.S; Premarin

Estrogen Derivative

• Estrogens, when used in females after menopause, may increase the risk of uterine cancer. Progestins may decrease this risk. A warning sign for cancer of the uterus is unusual vaginal bleeding. Report any unusual vaginal bleeding to healthcare provider.

• Do not take estrogens if you are pregnant. If you become pregnant while taking this medicine, call healthcare provider right away.

• Do not take estrogens to prevent heart disease or dementia. Using estrogens may increase your chances of having a heart attack, a stroke, breast cancer, or a blood clot.

• This medicine does not mix well with some medicines. Serious reactions may occur. Check all medicines with healthcare provider.

• If you have an allergy to estrogens, conjugated (equine) or any other part of this medicine.

• Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other symptoms involved.

• If you have any of the following conditions: Blood clots, breast cancer (except in certain cases where the cancer has spread), liver disease, recent heart attack, recent stroke, tumor where estrogen makes it grow, or unexplained vaginal bleeding.

• If you have major surgery and need bedrest.

• If you are pregnant or may be pregnant.

• Estrogens are used as an estrogen replacement.

• It reduces bone destruction.

• Take this medicine at a similar time of day.

• There may be days when you will not take this medicine.

• Take tablet with food.

• Use cream vaginally.

Osteoporosis:

• This medicine works best when used with calcium/vitamin D supplements and weight-bearing exercises like walking or physical therapy.

• Follow diet plan and exercise program as recommended by healthcare provider.

Injection:

• This medicine is given as a shot into a muscle or vein.

• Take a missed dose as soon as possible.

• If it is almost time for the next dose, skip the missed dose and return to your regular schedule.

• Do not take a double dose or extra doses.

• Do not change dose or stop medicine. Talk with healthcare provider.

• Change in condition being treated. Is it better, worse, or about the same?

• If you are taking a blood thinner, check blood work (prothrombin time/INR). Talk with healthcare provider.

• Check blood pressure and heart rate regularly. Talk with healthcare provider.

• If you are diabetic, you will need to monitor blood sugars closely.

• Check blood work (cholesterol panel). Talk with healthcare provider.

• Have a yearly eye exam.

• Bone density test.

• Periodic breast (monthly self-exam) and yearly gynecologic exams are important.

• Follow up with healthcare provider yearly.

• Store at room temperature.

• Protect tablets from moisture. Do not store in a bathroom or kitchen.

• The injection will be given to you in a healthcare setting. You will not store it at home.

• If you have a life-threatening allergy, wear allergy identification at all times.

• Do not share your medicine with others and do not take anyone else's medicine.

• Keep all medicine out of the reach of children and pets.

• Most medicines can be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.

• Keep a list of all your medicines (prescription, natural products, supplements, vitamins, over-the-counter) with you. Give this list to healthcare provider (doctor, nurse, nurse practitioner, pharmacist, physician assistant).

• Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or in Canada to Health Canada's Canada Vigilance Program at 1-866-234-2345.

• Talk with healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins.

• Read the package insert for more details.

Created: 2006-10-13 12:23:27.0

Modified: 2010-05-07 09:52:28.0

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