Estradiol and Norethindrone Side Effects and Warnings

What are the precautions when taking this medicine?

• There may be a higher risk of breast cancer.

• The patch may contain conducting metal. Remove patch before MRI.

• If you have any circulation problems, talk with healthcare provider.

• If you have high blood pressure, talk with healthcare provider.

• If you have a weakened heart, talk with healthcare provider.

• Check medicines with healthcare provider. This medicine may not mix well with other medicines.

• Limit alcohol intake (includes wine, beer, and liquor).

• Use birth control that you can trust to prevent pregnancy while taking this medicine.

• Tell healthcare provider if you are breast-feeding.

What are some possible side effects of this medicine?

• Headache.

• Belly pain.

• Nausea or vomiting. Small frequent meals, frequent mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.

• Breast enlargement.

• Change in sexual ability or desire. This is usually reversible.

Reasons to call healthcare provider immediately

• If you suspect an overdose, call your local poison control center or emergency department immediately.

• Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.

• Chest pain or pressure.

• Difficulty breathing.

• Change in strength on one side greater than the other, difficulty speaking or thinking, change in balance, or blurred vision.

• Swelling or pain of leg or arm.

• Severe headache.

• Severe nausea or vomiting.

• Change in contact lens tolerance.

• Sudden change in vision, eye pain, or irritation.

• A lump in the breast or breast tenderness.

• For females, menstrual changes. These include lots of bleeding, spotting, or bleeding between cycles.

• Any rash.

• No improvement in condition or feeling worse.