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Safety Issues
Corydalis has not undergone any meaningful safety testing. The herb is known to produce immediate side effects, including nausea and fatigue, in some people. In addition, there are serious safety concerns related to its alkaloid constituent THP. Use of products containing THP has repeatedly been associated with severe and potentially fatal liver injury. 1 2 3 4 5 In addition, there are three reports that use of THP by young children has led to life-threatening suppression of the central nervous system. 6 For these reasons, we strongly recommend against the use of corydalis, especially by young children, pregnant or nursing women, or people with liver disease.
References
- McRae CA, Agarwal K, Mutimer D, Bassendine MF. Hepatitis associated with Chinese herbs. Eur J Gastroenterol Hepatol. 14(5):559-62.
- Stickel F, Egerer G, Seitz HK. Hepatotoxicity of botanicals. Public Health Nutr. 3(2):113-24.
- Picciotto A, Campo N, Brizzolara R, Giusto R, Guido G, Sinelli N, Lapertosa G, Celle G. Chronic hepatitis induced by Jin Bu Huan. J Hepatol. 28(1):165-7.
- Horowitz RS, Feldhaus K, Dart RC, Stermitz FR, Beck JJ. The clinical spectrum of Jin Bu Huan toxicity. Arch Intern Med. 156(8):899-903.
- Kaptchuk TJ. Acute hepatitis associated with jin bu huan. Ann Intern Med. 122(8):636.
- Jin Bu Huan toxicity in children—Colorado, 1993. MMWR Morb Mortal Wkly Rep. 1993;42:633-6.
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