Unfortunately, there is yet no evidence that it works for chronic fatigue syndrome, but this may be in part due to the fact that extensive research on licorice has not yet been conducted. However, other treatments to raise blood pressure have thus far proven to be ineffective for chronic fatigue syndrome.24
Based on the theory mentioned above that CFS might be related to low blood pressure, the herb licorice has been recommended for CFS by some herbalists. Licorice raises blood pressure (and causes other potentially harmful effects) when taken in high doses for a long time.
Licorice root has been used across many traditions as an herbal treatment for many different conditions. Some herbalists or Traditional Chinese Medicine practitioners might recommend taking licorice root to treat chronic fatigue.