Bromelain appears to be essentially nontoxic, and it seldom causes side effects other than occasional mild gastrointestinal distress or allergic reactions. 1 However, because bromelain "thins" the blood to some extent, it shouldn't be combined with drugs such as warfarin (Coumadin) without a doctor's supervision.
According to one small animal study, bromelain might interact with sedative medications, increasing their effect. 2 As noted above, it might also increase blood levels of various antibiotics , which could present risks in some cases. In addition, one trial suggests that doses of bromelain eight times higher than standard recommendations might increase heart rate (but not blood pressure). 3 Safety in young children, pregnant or nursing women, or those with liver or kidney disease has not been established.
Bromelain and other proteolytic enzymes are sometimes recommended for the treatment of carpal tunnel syndrome, but there is no concrete evidence as yet that they are effective. It is thought that this supplement might help through its ability to reduce some inflammation.
Bromelain, or proteolytic enzymes, are enzymes produced by the body that help digest the proteins in food.
The primary use of proteolytic enzymes is as a digestive aid for people who have trouble digesting proteins. However, proteolytic enzymes may also be absorbed internally to some extent and may reduce pain and inflammation (symptoms in with those with carpal tunnel syndrome.)
Bromelain and other proteolytic enzymes are sometimes recommended for the treatment of carpal tunnel syndrome, but there is no concrete evidence as yet that they are effective. It is thought that this supplement might help through its ability to reduce some inflammation.
Bromelain is not actually a single substance, but rather a collection of protein-digesting enzymes (also called proteolytic enzymes) found in pineapple juice and in the stem of pineapple plants. It is primarily produced in Japan, Hawaii, and Taiwan, and much of the original research was performed in the first two of those locations. Subsequently, European researchers developed an interest, and, by 1995, bromelain had become the thirteenth most common individual herbal product sold in Germany.
However, the only support for the use of bromelain as a treatent for sinusitis comes from a few poor-quality, double-blind studies performed in the 1960s.4-6 It is not apparent from the published study reports whether the participants in these studies had viral or bacterial sinusitis.
Bromelain is not actually a single substance, but rather a collection of protein-digesting enzymes (also called proteolytic enzymes) found in pineapple juice and in the stem of pineapple plants.
The enzyme bromelain has also been advocated for treatment of sinusitis.
