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Extracts are usually standardized to contain a 70 percent silymarin complex. The typical dose is 200 to 420 mg daily taken thice daily with meals for 2 months, then 280 mg/day in three divided doses. There are no known side effects or contraindications. While milk thistle has not shown any side effects in scientific tests, if you are pregnant or lactating, please consult your health care provider before taking milk thistle. Discontinue use for 2 to 7 days every 8 weeks to maintain peak effectiveness.
Overall, studies demonstrate that a standardized milk thistle extract protects the liver, including daily exposure to environmental pollutants, side effects of certain medications, chronic alcohol use, cirrhosis and fatty degeneration of the liver. This herb is does not have any reported interactions with prescription medications. While studies have not yet been conducted on milk thistle and migraine, one study conducted on chronic migraine sufferers that saw an 80% improvement rate over 90 days included milk thistle extract as a key ingredient.
Milk thistle is a herbal native to Asia, Africa, Europe and southern Russia. Its medicinal properties are found in the seeds, or achenes, after the plant flowers.
Milk Thistle is a well-known and studied herb that enhances liver function and stimulates regeneration of hepatic cells when mild to moderately damaged. Due to the liver’s role in detoxifying the blood, and the possible role of toxins in the blood stimulating inflammation and abnormal contraction of the blood vessels, milk thistle has been shown to reduce the number of migraine attacks in chronic sufferers, possibly pointing to a link between digestion, elimination and the inflammation in the blood vessels.
Milk thistle seeds contain a group of flavonolignans--which are believed to be the plant's active constituents, and as a group, are known as silymarin. Silymarin is a group of flavonolignans, and silybinin, the major constituent, along with isosilybin, dihydrosilybin, silydianin, silychristin, and a few flavonoids. The seeds also contains 20 to 30 percent oil (a combination of fatty acids that are solid at room temperature), mucilage, protein and taxifolin, a naturally-ocurring plant chemical that has demonstrated beneficial properties on lipid and fat metabolism in pre-liminary tests.
Inflammation is demonstrated to play a central role in the symptoms of migraine. Finnish researchers conducted a double-blind, controlled study to understand the effect of milk thistle seed extract on liver inflammation. They measured levels of an enzyme released from inflamed liver cell in 97 patients. Subjects who received the milk thistle versus the placebo showed a statistically significant decrease in liver enzymes.
