Research suggests that chelation therapy is probably ineffective.14,15 For more information, see the research section of the article on chelation therapy for coronary artery disease and angina.
Enter section content.. EDTA is a synthetic substance that is used to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in treating hardening of the arteries. (The damaged, brittle vessels found in people with heart disease are lined with calcium deposits.) Chelation therapy may help treat people at risk of or recovering from heart attacks by helping to improve the health and function of these hardened arteries.
Some alternative medicine physicians recommend use of intravenous infusions of a chemical called ethylenediaminetetraacetic acid (EDTA) in order to clear out the arteries of the heart, a method called chelation therapy.
Chelation therapy is controversial. It is widely promoted for the treatment of angina, but there is no meaningful evidence that it is effective, and some evidence that it is not. Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits. Many other experts argue that chelation therapy is based on an outmoded outdated understanding of atherosclerosis.
Some physicians and alternative practitioners believe in chelation therapy and may offer it.
Research suggests that chelation therapy is probably ineffective.14,15 For more information, see the research section of the article on chelation therapy for coronary artery disease and angina.
Some alternative medicine physicians recommend use of intravenous infusions of a chemical called ethylenediaminetetraacetic acid (EDTA) in order to clear out the arteries of the heart, a method called chelation therapy.
Chelation therapy is controversial. It is widely promoted for the treatment of angina, but there is no meaningful evidence that it is effective, and some evidence that it is not. Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits. Many other experts argue that chelation therapy is based on an outdated understanding of atherosclerosis.
EDTA is a synthetic substance that is used to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in treating hardening of the arteries. (The damaged, brittle vessels found in people with heart disease are lined with calcium deposits.) Chelation therapy may help treat people at risk of or recovering from heart attacks by helping to improve the health and function of these hardened arteries.
Not only does it appear to be ineffective, EDTA chelation therapy may present some safety risks. This treatment is generally given in a series of 10 to 30 sessions. If the practitioner fails to take proper precautions, severe adverse consequences, such as kidney damage, may result. While it appears to be the case that properly Properly performed chelation therapy is unlikely to cause harm, we do not see any justification for using such an invasive method, in the absence of evidence that it will help.
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EDTA is a synthetic substance that is used to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in treating hardening of the arteries. (The damaged, brittle vessels found in people with heart disease are lined with calcium deposits.)
Chelation therapy for heart disease consists of intravenous infusions of a chemical called EDTA (ethylenediaminetetraacetic acid). This synthetic substance is used in conventional medicine to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in treating hardening of the arteries. (The damaged, brittle vessels found in people with heart disease are lined with calcium deposits.)
Chelation therapy is controversial. It is widely promoted for the treatment of angina, but there is no meaningful evidence that it is effective, and some evidence that it is not. 9,20,21 Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits.
In 2000, a highly respected researcher reviewed the literature on chelation therapy and concluded, “The most striking finding is the almost total lack of convincing evidence for efficacy…. Only 2 controlled clinical trials were located. They provide no evidence that chelation therapy is efficacious beyond a powerful placebo effect…. Given the potential of chelation therapy to cause severe adverse effects, this treatment should now be considered obsolete.”1
Subsequent to this review, a well-designed study compared chelation therapy to placebo in 84 people with coronary artery disease.2 People receiving EDTA chelation showed improvement; however, those receiving placebo also improved—to the same extent.
Another double-blind study evaluated the potential benefits of chelation therapy when added to conventional therapy in the treatment of people with coronary artery disease (CAD).3 Researchers were looking for improvements in the ability of a blood vessel in the arm (the brachial artery) to dilate, but did not find any. However, this study had several limitations in its design, making its results less meaningful than they might have been.
Chelation therapy for heart disease consists of intravenous infusions of a chemical called EDTA (ethylenediaminetetraacetic acid).
Chelation therapy is controversial. It is widely promoted for the treatment of angina, but there is no meaningful evidence that it is effective, and some evidence that it is not. Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits.
EDTA is a synthetic substance that is used to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in treating hardening of the arteries. (The damaged, brittle vessels found in people with heart disease are lined with calcium deposits.)
When medical researchers first investigated the phenomenon known as hardening of the arteries (closely related to atherosclerosis ), they discovered that the damaged, brittle vessels found in people with heart disease were lined with calcium deposits. Naturally, this finding inspired the notion that calcium deposits were the cause of the problem.
Some early researchers investigated the possible therapeutic effect of removing such deposits. However, subsequent research indicated that the calcium deposits of atherosclerosis were a symptom rather than a cause, and mainstream interest turned elsewhere. Certain physicians nonetheless maintained an interest in removing calcium; thus chelation therapy was born.
Chelation therapy for heart disease consists of intravenous infusions of a chemical called EDTA (ethylenediaminetetraacetic acid). This synthetic substance is used in conventional medicine to remove heavy metals, such as lead, from the body, but it also has an effect on calcium, which is why it came into use in chelation therapy.
Proponents claim that EDTA chelation is an effective alternative to heart surgery, and that it also offers many other health benefits. To support this, they cite numerous anecdotes of cures apparently brought about by its use. However, anecdotes cannot possibly prove a treatment effective. (For a detailed explanation of why this is the case, see Why Does This Database Rely on Double-blind Studies? ) Only double-blind, placebo-controlled trials can do so, and thus far such studies have failed to find chelation therapy effective.
In 2000, a highly respected researcher reviewed the literature on chelation therapy and concluded, “The most striking finding is the almost total lack of convincing evidence for efficacy…. Only 2 controlled clinical trials were located. They provide no evidence that chelation therapy is efficacious beyond a powerful placebo effect…. Given the potential of chelation therapy to cause severe adverse effects, this treatment should now be considered obsolete.” 1 Subsequent to this review, a well-designed study compared chelation therapy to placebo in 84 people with coronary artery disease. 2 People receiving EDTA chelation showed improvement; however, those receiving placebo also improved—to the same extent! This finding reminds us why double-blind, placebo-controlled studies are necessary to establish the effectiveness of a treatment. If researchers had performed this study without a placebo group, they might have concluded that EDTA chelation really works. Instead, the fact that the same level of benefits was seen in the fake-treatment group indicates that chelation therapy does not work.
Another double-blind study evaluated the potential benefits of chelation therapy when added to conventional therapy in the treatment of people with coronary artery disease. 3 Researchers were looking for improvements in the ability of a blood vessel in the arm (the brachial artery) to dilate, but did not find any. However, this study had several limitations in its design, making its results less meaningful than they might have been.
