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Therapeutic Uses
Androstenedione is said to enhance athletic performance and strength by increasing testosterone production, thereby building muscle. However, in double-blind studies, when androstenedione was given to men, it did not alter total testosterone levels, nor improve sports performance, strength, or lean body mass. 1 It did, however, increase estrogen levels, an effect that would not be considered favorable. Curiously, some evidence suggests that androstenedione does raise testosterone levels levels in women; again, this is not likely to produce favorable results, and it could cause harm (see Safety Issues ). 2 The most consistent effect of androstenedione is to increase estrogen levels.
References
- Leder BZ, Longcope C, Catlin DH, Ahrens B, Schoenfeld DA, Finkelstein JS. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA. 283(6):779-82.
- Leder BZ, Leblanc KM, Longcope C, Lee H, Catlin DH, Finkelstein JS. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab. 87(12):5449-54.